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Open Access Articles- Top Results for DAPK1

DAPK1

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Identifiers
SymbolsDAPK1 ; DAPK
External IDsOMIM600831 MGI1916885 HomoloGene3626 IUPHAR: 2002 ChEMBL: 2558 GeneCards: DAPK1 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE DAPK1 203139 at tn.png
File:PBB GE DAPK1 211214 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez161269635
EnsemblENSG00000196730ENSMUSG00000021559
UniProtP53355Q80YE7
RefSeq (mRNA)NM_001288729NM_001285917
RefSeq (protein)NP_001275658NP_001272846
Location (UCSC)Chr 9:
90.11 – 90.32 Mb
Chr 13:
60.6 – 60.76 Mb
PubMed search[1][2]

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[1]

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[2]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.[3]

References

  1. ^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics 29 (1): 305–7. PMID 8530096. doi:10.1006/geno.1995.1255. 
  2. ^ "Entrez Gene: DAPK1 death-associated protein kinase 1". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x. 

Further reading

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