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Open Access Articles- Top Results for DAPK3

DAPK3

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Identifiers
SymbolsDAPK3 ; DLK; ZIP; ZIPK
External IDsOMIM603289 MGI1203520 HomoloGene20353 IUPHAR: 2004 ChEMBL: 2468 GeneCards: DAPK3 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE DAPK3 203891 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez161313144
EnsemblENSG00000167657ENSMUSG00000034974
UniProtO43293O54784
RefSeq (mRNA)NM_001348NM_001190473
RefSeq (protein)NP_001339NP_001177402
Location (UCSC)Chr 19:
3.96 – 3.97 Mb
Chr 10:
81.18 – 81.19 Mb
PubMed search[1][2]

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[1][2]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[3]

Interactions

DAPK3 has been shown to interact with PAWR[4] and Death associated protein 6.[4]

References

  1. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Mol Cell Biol 18 (3): 1642–51. PMC 108879. PMID 9488481. 
  2. 2.0 2.1 "Entrez Gene: DAPK3 death-associated protein kinase 3". 
  3. Shoval Y, Pietrokovski S, Kimchi A (October 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genet. 3 (10): 1884–93. PMC 2041995. PMID 17953487. doi:10.1371/journal.pgen.0030180. 
  4. 4.0 4.1 Kawai T, Akira S, Reed JC (September 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Mol. Cell. Biol. 23 (17): 6174–86. PMC 180930. PMID 12917339. doi:10.1128/MCB.23.17.6174-6186.2003. 

Further reading

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