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DIDO1

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Identifiers
SymbolsDIDO1 ; BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8
External IDsOMIM604140 MGI1344352 HomoloGene34139 GeneCards: DIDO1 Gene
RNA expression pattern
File:PBB GE DIDO1 218325 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1108323856
EnsemblENSG00000101191ENSMUSG00000038914
UniProtQ9BTC0Q8C9B9
RefSeq (mRNA)NM_001193369NM_001291432
RefSeq (protein)NP_001180298NP_001278361
Location (UCSC)Chr 20:
61.51 – 61.57 Mb
Chr 2:
180.66 – 180.71 Mb
PubMed search[1][2]

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.[1][2]

Function

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[2]

References

  1. ^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development". Proc Natl Acad Sci U S A 96 (14): 7992–7. PMC 22175. PMID 10393935. doi:10.1073/pnas.96.14.7992. 
  2. ^ a b "Entrez Gene: DIDO1 death inducer-obliterator 1". 

Further reading

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External links


Template:Gene-20-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.