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Open Access Articles- Top Results for DMCM

DMCM

DMCM
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This page is a soft redirect. Names

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IUPAC name
methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[5,4-b]indole-3-carboxylate
Other names
DMCM
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82499-00-1 7pxY
ChemSpider 94746 7pxN
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C17H18N2O4
Molar mass 314.336 g/mol
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as an inverse agonist of benzodiazepine receptors, meaning that it causes the opposite effects to the benzodiazepine class of drugs. As such, DMCM has anxiogenic and convulsant properties,[1] and is used in scientific research to induce anxiety so that new anxiolytic medications can be tested,[2] and to produce convulsions so that anticonvulsant medications can be tested.[3][4][5] It has also been shown to produce analgesic effects in animals, thought to be because it produces panic which reduces the perception of pain.[6]

References

  1. Contó, MB; De Carvalho, JG; Benedito, MA (2005). "Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist". Pharmacology, Biochemistry, and Behavior 82 (3): 417–26. PMID 16297441. doi:10.1016/j.pbb.2005.09.012. 
  2. Cole, BJ; Hillmann, M; Seidelmann, D; Klewer, M; Jones, GH (1995). "Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat". Psychopharmacology 121 (1): 118–26. PMID 8539336. doi:10.1007/BF02245598. 
  3. Brodie, MJ (1995). "Tiagabine pharmacology in profile". Epilepsia. 36 Suppl 6: S7–S9. PMID 8595791. doi:10.1111/j.1528-1157.1995.tb06015.x. 
  4. De Sarro, G; Chimirri, A; McKernan, R; Quirk, K; Giusti, P; De Sarro, A (1997). "Anticonvulsant activity of azirino1,2-d1,4benzodiazepines and related 1,4-benzodiazepines in mice". Pharmacology, Biochemistry, and Behavior 58 (1): 281–9. PMID 9264104. doi:10.1016/S0091-3057(96)00565-5. 
  5. Leppä, E; Vekovischeva, OY; Lindén, AM; Wulff, P; Oberto, A; Wisden, W; Korpi, ER (2005). "Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice". Neuropharmacology 48 (4): 469–78. PMID 15755475. doi:10.1016/j.neuropharm.2004.11.007. 
  6. Sieve, AN; King, TE; Ferguson, AR; Grau, JW; Meagher, MW (2001). "Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats". Psychopharmacology 153 (2): 180–90. PMID 11205417. doi:10.1007/s002130000535. 



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