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Open Access Articles- Top Results for DS-1 (drug)

DS-1 (drug)

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DS-1
File:DS-1 structure.png
Systematic (IUPAC) name
4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl]benzamide
Clinical data
Identifiers
372497-52-4 7pxY
PubChem CID 979735
Chemical data
Formula C18H10Br2ClN3OS
511.617 g/mol
 14pxY (what is this?)  (verify)

DS-1 is a drug from the imidazopyridine family, which is the first drug developed that acts as a GABAA receptor positive allosteric modulator (PAM) selective for the α4β3δ subtype, which is not targeted by other GABAA receptor PAMs such as the benzodiazepines or other nonbenzodiazepine drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.[1]

See also

References

  1. ^ Wafford, KA; Van Niel, MB; Ma, QP; Horridge, E; Herd, MB; Peden, DR; Belelli, D; Lambert, JJ (2009). "Novel compounds selectively enhance delta subunit containing GABA a receptors and increase tonic currents in thalamus". Neuropharmacology 56 (1): 182–9. PMID 18762200. doi:10.1016/j.neuropharm.2008.08.004. 



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