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Open Access Articles- Top Results for Dacemazine

Dacemazine

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Dacemazine
260px
Systematic (IUPAC) name
2-dimethylamino-1-phenothiazin-10-ylethanone
Clinical data
Identifiers
518-61-6 7pxN
None
PubChem CID 68846
ChemSpider 62079 7pxY
UNII verifiedrevid = 460112476 88D34UY0QI verifiedrevid = 460112476 7pxN
ChEMBL CHEMBL2107547 7pxN
Chemical data
Formula C16H16N2OS
284.376 g/mol
 14pxN (what is this?)

Dacemazine (INN, also known as Ahistan and Histantine)[1] is a phenothiazine derivative which acts as an histamine antagonist at the H1 subtype. First described in 1951, it was never marketed as a drug on its own, although a combination of dacemazine and di-tert-butylnaphthalenesulfonate was sold as an antispasmodic and antitussive under the trade name Codopectyl.[1] It was also assessed as a possible anticancer drug.[2]

References

  1. ^ a b David J. Triggle; C. R. Ganellin; F. MacDonald (1996). Dictionary of Pharmacological Agents 1. Boca Raton: Chapman & Hall/CRC. pp. p. 711. ISBN 0-412-46630-9.  Retrieved on August 2, 2008 through Google Book Search.
  2. ^ Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C. The anticarcinogenic effect of dimethylaminoacetyl-phentiazide (ahistan). Kiserletes Orvostudomany. 1952 Aug;4(4):260-2. PMID 13023855


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