Open Access Articles- Top Results for Death receptor 4

Death receptor 4

SymbolsTNFRSF10A ; APO2; CD261; DR4; TRAILR-1; TRAILR1
External IDsOMIM603611 MGI1341090 HomoloGene129806 IUPHAR: 1879 ChEMBL: 3551 GeneCards: TNFRSF10A Gene
RefSeq (mRNA)NM_003844NM_020275
RefSeq (protein)NP_003835NP_064671
Location (UCSC)Chr 8:
23.05 – 23.08 Mb
Chr 14:
69.77 – 69.78 Mb
PubMed search[1][2]

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.[1][2]


The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[3]


TNFRSF10A has been shown to interact with DAP3.[4]


  1. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT (Dec 1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J 16 (17): 5386–97. PMC 1170170. PMID 9311998. doi:10.1093/emboj/16.17.5386. 
  2. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM (April 1997). "The receptor for the cytotoxic ligand TRAIL". Science 276 (5309): 111–3. PMID 9082980. doi:10.1126/science.276.5309.111. 
  3. "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a". 
  4. Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. (United States) 2 (6): 493–500. ISSN 1529-2908. PMID 11376335. doi:10.1038/88684. 

Further reading