Open Access Articles- Top Results for Decitabine


Systematic (IUPAC) name
Clinical data
Trade names Dacogen
AHFS/ monograph
MedlinePlus a608009
  • D
  • (Prescription only)
Pharmacokinetic data
Protein binding <1%
Half-life 30 minutes
2353-33-5 7pxY
PubChem CID 451668
DrugBank DB01262 7pxY
ChemSpider 397844 7pxY
UNII 776B62CQ27 7pxY
KEGG D03665 7pxY
ChEBI CHEBI:50131 7pxY
ChEMBL CHEMBL1201129 7pxN
Chemical data
Formula C8H12N4O4
228.206 g/mol
 14pxN (what is this?)  (verify)

Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, is a drug for the treatment of myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML).[1] Chemically, it is a cytidine analog.


Decitabine is a hypomethylating agent.[2][3] It hypomethylates DNA by inhibiting DNA methyltransferase.

It functions in a similar manner to azacitidine, although decitabine can only be incorporated into DNA strands while azacitidine can be incorporated into both DNA and RNA chains.

Clinical uses

Decitabine is indicated for the treatment of myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and Intermediate-1, Intermediate-2, and High-Risk International Prognostic Scoring System groups. In patients with renal insufficiency, Batty and colleagues reported the first case series on the feasibility of therapy with hypomethylating agents in patients with renal insufficiency.[4]


  1. ^ "EC Approves Marketing Authorization Of DACOGEN For Acute Myeloid Leukemia". 2012-09-28. Retrieved 28 September 2012. 
  2. ^ Kantarjian H, Issa JP, Rosenfeld CS et al. (April 2006). "Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study". Cancer 106 (8): 1794–1803. PMID 16532500. doi:10.1002/cncr.21792. 
  3. ^ Kantarjian HM, O'Brien S, Cortes J et al. (August 2003). "Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia". Cancer 98 (3): 522–528. PMID 12879469. doi:10.1002/cncr.11543. 
  4. ^ Ravandi, F.; Kantarjian, J. E.; Issa, S.; Jabbour, S.; Santos, G.; McCue, D.; Garcia-Manero, F. P. S.; Pierce, E.; O'Brien, J. P.; Cortés, J. E.; Ravandi, F. (2010). "Feasibility of Therapy with Hypomethylating Agents in Patients with Renal Insufficiency". Clinical Lymphoma, Myeloma & Leukemia 10 (3): 205–210. PMC 3726276. PMID 20511166. doi:10.3816/CLML.2010.n.032.  edit

Further reading

External links

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