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Demoxepam

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Demoxepam
180px
Systematic (IUPAC) name
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-4-oxide
Clinical data
Pharmacokinetic data
Half-life 35 to 40 h
Identifiers
963-39-3 7pxN
PubChem CID 13756
ChemSpider 10441314 7pxY
UNII 8X1XP5M0SB 7pxY
KEGG D02600 7pxY
ChEMBL CHEMBL1597677 7pxN
Chemical data
Formula C15H11ClN2O2
286.713
 14pxN (what is this?)  (verify)

Demoxepam[1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties[2][3] and presumably other characteristic benzodiazepine properties.

Synthesis

Demoxepam is also an intermediate in the synthesis of oxazepam; it is also used in one of the syntheses of medazepam. It can be considered directly analogous/synonoymous with the synthesis of chlordiazepoxide, with the exception that instead of methylamine, hydroxide ion is the choice of base; here acid is not used for the cyclodehydration step though.

File:Demoxepam synthesis.svg
Demoxepam synthesis: Reeder Earl, Sternbach Leo Henryk, U.S. Patent 3,136,815 (1959 to Hoffmann La Roche).

See also

References

  1. ^ US Patent 3136815
  2. ^ "nortetrazepam". psychotropics.dk. 2003. Retrieved 7 December 2009. 
  3. ^ "LIST OF INTERNATIONAL NON-PROPRIETARY NAMES (INNS), PROVIDED FOR PHARMACEUTICAL SUBSTANCES BY THE WORLD HEALTH ORGANIZATION, WHICH ARE FREE OF DUTY" (PDF). Official Journal of the European Communities (eur-lex.europa.eu). 23 October 2001. Retrieved 7 December 2009. 


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