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Dermatan sulfate

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Dermatan sulfate
File:Dermatan sulfate.PNG
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
24967-94-0 7pxY
B01AX04
ChEMBL CHEMBL1909290 7pxN
Chemical data
Formula C14H21NO15S2
 14pxN (what is this?)  (verify)

Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.

It is also referred to as chondroitin sulfate B, [1] although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C14H21NO15S.

Function

Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.[2]

Pathology

Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.

An excess of dermatan sulfate in the mitral valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, mitral valve prolapse (into the left atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification. Mitral valve insufficiency can lead to eccentric (volume dependent or dilated) hypertrophy and eventually left heart failure if untreated.

See also

External links

References

  1. ^ Trowbridge, JM; Gallo, RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology 12 (9): 117R–25R. PMID 12213784. doi:10.1093/glycob/cwf066. 
  2. ^ Janet M. Trowbridge and Richard L. Gallo (2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology 12 (9): 117R–125R. PMID 12213784. doi:10.1093/glycob/cwf066. 

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