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Open Access Articles- Top Results for Dexoxadrol

Dexoxadrol

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Dexoxadrol
150px
Systematic (IUPAC) name
(2S)-2-[(4S)-2,2-di(phenyl)-1,3-dioxolan-4-yl]piperidine
Clinical data
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Identifiers
6495-46-1 7pxN
None
PubChem CID 3034023
ChemSpider 2298576 7pxY
UNII Verifiedfields = changed JY5N9F45AG Verifiedfields = changed 7pxN
ChEMBL CHEMBL1165411 7pxY
Chemical data
Formula C20H23NO2
309.40 g/mol
 14pxN (what is this?)  (verify)

Dexoxadrol (Dioxadrol) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations.[1][2]

See also

References

  1. ^ Sax, M.; Wünsch, B. (2006). "Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity". Current Topics in Medicinal Chemistry 6 (7): 723–732. PMID 16719812. doi:10.2174/156802606776894483. 
  2. ^ Aepkers, M.; Wünsch, B. (2005). "Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol". Bioorganic and Medicinal Chemistry 13 (24): 6836–6849. PMID 16169732. doi:10.1016/j.bmc.2005.07.030. 


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