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Dichloroisoprenaline

Dichloroisoprenaline
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This page is a soft redirect. Names

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Preferred IUPAC name
Dichloroisoprenaline
Systematic IUPAC name
1-(3,4-Dichlorophenyl)-2-[(propan-2-yl)amino]ethan-1-ol
Other names
1-(3,4-Dichlorophenyl)-2-(isopropylamino)ethanol
Dichlorisoproterenol
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59-61-0 7pxN
ChEBI CHEBI:144234 7pxN
ChEMBL ChEMBL30816 7pxY
ChemSpider 5601 (1R) 7pxY
5324297 (1S) 7pxY
5601 () 7pxY
Jmol-3D images Image
Image
KEGG C11772 7pxN
MeSH Dichloroisoproterenol
PubChem Template:Chembox PubChem/formatTemplate:Chembox PubChem/formatTemplate:Chembox PubChem/format
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This page is a soft redirect. Properties

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C11H15Cl2NO
Molar mass 248.15 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

Dichloroisoprenaline (DCI), also known as dichloroisoproterenol, was the first beta blocker ever to be developed. It is non-selective for the β1-adrenergic and β2-adrenergic receptors. DCI has low potency and acts as a partial agonist/antagonist at these receptors.[1]

Although DCI was of no clinical value itself, further developments from DCI eventually led to the development of the clinical candidate pronethalol (withdrawn due to carcinogenicity) and subsequently propranolol (the first clinically successful beta blocker).

Dichloroisoprenaline is a racemic mixture of enantiomers.

References

  1. W. E. Glover, A. D. M. Greenfield, and R. G. Shanks (October 1962). "Effect of dichloroisoprenaline on the peripheral vascular responses to adrenaline in man". Br J Pharmacol Chemother 19: 235–244. PMC 1482134. PMID 13948521. doi:10.1111/j.1476-5381.1962.tb01185.x. 


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