Open Access Articles- Top Results for Dicycloverine


Systematic (IUPAC) name
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
Clinical data
Trade names Byclomine, Bentyl, Dibent, Di-Spaz, Dilomine
AHFS/ International Drug Names
MedlinePlus a684007
  • AU: B1
  • US: B (No risk in non-human studies)
Pharmacokinetic data
Protein binding >99%
Half-life 5 h
77-19-0 7pxY
PubChem CID 3042
IUPHAR ligand 355
DrugBank DB00804 7pxY
ChemSpider 2934 7pxY
KEGG D07820 7pxY
ChEBI CHEBI:4514 7pxY
Chemical data
Formula C19H35NO2
309.487 g/mol
 14pxY (what is this?)  (verify)

Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.[1]

Medical uses

File:Dicyclomine Hydrochloride 10 MG Oral Capsule.jpg
A 10-mg oral capsule of dicyclomine hydrochloride, manufactured by Mylan

Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[2]

In the UK, it is an ingredient of a multiple-ingredient preparation, with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon. In France, it is an ingredient of a multiple-ingredient preparation, with colchicine, under the brand Colchimax. In India, it is of a compound with paracetamol under the trade name Cyclopam. It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic. Also it is a part of Normaxin containing two other salts clidinium bromide and chlordiazepoxide.

Side effects

Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.[2] Recreational use of this drug for its anticholinergic effects (both low dose for euphoria and high dose for delirium) has been rarely reported; it is also reputed to cause a rapid increase in libido in the first 10-135 minutes after dosing.


Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[2]

See also


  1. Tilford, C. H.; Campen, M. G. V.; Shelton, R. S. (1947). "Aminoesters of Substituted Alicylic Carboxylic Acids1". Journal of the American Chemical Society 69 (11): 2902. doi:10.1021/ja01203a077.  edit
  2. 2.0 2.1 2.2 "Dicyclomine hydrochloride". Monograph. 

Further reading

  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

External links

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