Open Access Articles- Top Results for Diethylcarbamazine


Systematic (IUPAC) name
Clinical data
AHFS/ Micromedex Detailed Consumer Information
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Pharmacokinetic data
Half-life .
90-89-1 7pxY
P02CB02 QP52AH02
PubChem CID 3052
DrugBank DB00711 7pxY
ChemSpider 2944 7pxY
UNII V867Q8X3ZD 7pxY
KEGG D07825 7pxY
Chemical data
Formula C10H21N3O
199.293 g/mol
 14pxY (what is this?)  (verify)

Diethylcarbamazine Citrate (DEC) (N, N-diethyl-4-methyl-1-piperazine carboxamide dihydrogen citrate) is a synthetic derivative of piperazine, used as an anthelmintic drug used in the treatment of filariasis in humans, dogs and cats. Discovery was attributed to Yellapragada Subbarow.

DEC is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]

Medical uses

DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.

In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because of the intense and unbearable itching associated with the dead subcutaneous parasites.

DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog heartworm Dirofilaria immitis.

Now WHO prescribes DEC to patients who are susceptible to filariasis by preventive regimen in endemic areas.

Contraindications are Previous history of heart problems, Gastrointestinal problems, allergic patients


DEC is an inhibitor of arachidonic acid metabolism in filarial microfilaria. This makes the microfilaria more susceptible to immune attack. However, DEC is not directly toxic to the filarial microfilaria.[2]

Trade names

  • Hetrazan
  • Carbilazine
  • Caricide
  • Cypip
  • Ethodryl
  • Notézine
  • Spatonin
  • Filaribits
  • Banocide Forte
  • Eofil


  1. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 
  2. ^ El-Shahawi, G. A.; Abdel-Latif, M; Saad, A. H.; Bahgat, M (2010). "Setaria equina: In vivo effect of diethylcarbamazine citrate on microfilariae in albino rats". Experimental Parasitology 126 (4): 603–10. PMID 20599991. doi:10.1016/j.exppara.2010.06.022.  edit