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Dihydropyridine

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Dihydropyridine

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This page is a soft redirect. Names

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Systematic IUPAC name
1,4-Dihydropyridine[1]
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3337-17-5 7pxY ChemSpider 94619 7pxY Jmol-3D images Image MeSH 1,4-dihydropyridine PubChem Template:Chembox PubChem/format colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
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Template:Chem/atomTemplate:Chem/atomTemplate:Chem/atomTemplate:Chem/atomTemplate:Chem/atom Molar mass 81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Dihydropyridine is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as Verapamil) which have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Class members

The L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries): These are derivatives of Dihydropyridine.

Name Image Brand name Discovered
Amlodipine Norvasc, Istin
Aranidipine
Azelnidipine
Barnidipine
Benidipine
Cilnidipine
Clevidipine
Cronidipine
Darodipine
Dexniguldipine
Efonidipine
Elnadipine
Elgodipine
Felodipine Renedil, Plendil
Flordipine
Furnidipine
Iganidipine
Isradipine
Lacidipine
Lemildipine
Lercanidipine Zanidip
Manidipine
Mesuldipine
Nicardipine Cardene
Nifedipine Adalat, Nifedical, Procardia
Niguldipine
Nimodipine Nimotop
Niludipine
Nilvadipine
Nisoldipine Sular
Nitrendipine
Olradipine
Oxodipine
Palonidipine
Pranidipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Watanidipine

See also

References

  1. ^ "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011. 

External links

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