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Open Access Articles- Top Results for Dihydroxyphenylglycine

Dihydroxyphenylglycine

For the antiviral drug, see ganciclovir.
Dihydroxyphenylglycine
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IUPAC name
(S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid
Other names
3,5-dihydroxyphenylglycine, DHPG, S-DHPG
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162870-29-3 7pxY
ChemSpider 11377133 7pxY
Jmol-3D images Image
Image
MeSH 3,5-dihydroxyphenylglycine
PubChem Template:Chembox PubChem/format
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C8H9N1O4
Molar mass 183.05 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

(S)-3,5-Dihydroxyphenylglycine or DHPG is a potent agonist of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5.

DHPG was the first agonist shown to be selective for group I mGluRs.[1] Agonist activity is found in only the (S)-isomer, and (S)-DHPG may be a partial agonist of group I mGluRs.[1]

(S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease.[1]

3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia.[2]

References

  1. ^ a b c Wiśniewski K.; Car, H. (2002). "(S)-3,5-DHPG: a review". CNS Drug Rev. 8 (1): 101–116. PMID 12070529. 
  2. ^ Müller, P.; Schütte, H. R. (May 1968). "m-Hydroxyphenylglycine and 3,5-dihydroxyphenylglycine, 2 new amino acids from the latex of Euphorbia helioscopia". Z. Naturforsch. B (in German) 23 (5): 659–663. PMID 4385921. 


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