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Open Access Articles- Top Results for Diiodohydroxyquinoline

Diiodohydroxyquinoline

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Diiodohydroxyquinoline
Skeletal formula of diiodohydroxyquinoline
Ball-and-stick model of the diiodohydroxyquinoline molecule
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IUPAC name
5,7-diiodoquinolin-8-ol
Other names
Diquinol, iodoxin, diiodoquin, amebaquin
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ATC code G01AC01
83-73-8 7pxY
ChEMBL ChEMBL86754 7pxN
ChemSpider 3597 7pxN
Jmol-3D images Image
KEGG D00581 7pxY
MeSH Iodoquinol
PubChem Template:Chembox PubChem/format
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C9H5I2NO
Molar mass 396.951
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN), can be used in the treatment of amoebiasis.[1]

It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism.[2]

It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.[3]

Susceptibility of Dientamoeba fragilis has been measured.[4]

Iodoquinol is an amebocide used against Entamoeba histolytica, and it is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. The mechanism of action is unknown. Iodoquinol is used for diseases caused by moderate intestinal amebiasis.

References

  1. ^ Ghaskadbi S, Vaidya VG (March 1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. PMID 2493578. doi:10.1016/0165-1218(89)90137-7. 
  2. ^ Gideon Online http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General.  Missing or empty |title= (help)
  3. ^ Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
  4. ^ Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F (May 1994). "Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole". Antimicrob. Agents Chemother. 38 (5): 1157–60. PMC 188168. PMID 8067755. doi:10.1128/aac.38.5.1157.