Open Access Articles- Top Results for Dipivefrine


This article is about the drug. It is not to be confused with Propyne.
Systematic (IUPAC) name
[2-(2,2-dimethylpropanoyloxy)-4- (1-hydroxy-2-methylamino-ethyl)- phenyl] 2,2-dimethylpropanoate
Clinical data
Trade names Propine
AHFS/ International Drug Names
MedlinePlus a686005
  • US: B (No risk in non-human studies)
52365-63-6 7pxY
PubChem CID 3105
DrugBank DB00449 7pxY
ChemSpider 2994 7pxY
UNII 8Q1PVL543G 7pxY
KEGG D02349 7pxY
ChEBI CHEBI:4646 7pxY
ChEMBL CHEMBL1201262 7pxN
Chemical data
Formula C19H29NO5
351.437 g/mol
 14pxN (what is this?)  (verify)

Dipivefrin (trade name Propine) is a prodrug of epinephrine, and is used to treat open-angle glaucoma.[1] It is available as a 0.1% ophthalmic solution.

Mechanism of action

The drug when applied over the cornea, penetrates it and is then hydrolysed to epinephrine by the esterases. It increases uveosacral outflow and also reduces aqueous formation (an α1 and α2 mediated action), thus reducing the intraocular pressure. It also increases the hydraulic conductivity of trabecular filtering cells (a β2 mediated action). It is preferred to epinephrine because it is longer acting, more consistent in its action and has better ocular tolerance.[1]


  1. ^ a b KD Tripari MD. Essentials of Medical Pharmacology (5 ed.). Jaypee Brothers Medical Publishers(P) Ltd. p. 88. ISBN 81-8061-187-6. 

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