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Doramectin

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Doramectin
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Systematic (IUPAC) name
(1'R,2S,4'S,5S,6R,8'R,10'E,12'R,13'S,14'E,20'R,21'R,24'S)-6-cyclohexyl-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-3',7',19'-trioxaspiro[pyran-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one
Clinical data
AHFS/Drugs.com International Drug Names
  • Veterinary use only
Injection, Topical and Oral
Identifiers
117704-25-3
QP54AA03
PubChem CID 9832750
ChemSpider 8008478 7pxY
UNII KGD7A54H5P 7pxY
KEGG D01129 7pxY
Chemical data
Formula C50H74O14
899.114
 14pxY (what is this?)  (verify)

Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.[1]

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as an injection and as a 5 mg/ml topical solution.

Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health[2]) in an 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine[3] and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.

Doramectin is also available for horses[3] as an oral flavored bioadhesive gel under the name Doraquest L.A. Oral Gel.[4] It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.

References

  1. Pfizer Animal Health. "DECTOMAX Injectable." Last accessed July 14, 2007.
  2. Agrovet Market Animal Health-Doramec L.A.
  3. 3.0 3.1 Agrovet Market Animal Health
  4. Agrovet Market Animal Health-Doraquest L.A. Oral Gel