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Open Access Articles- Top Results for Dyclonine

Dyclonine

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Dyclonine
File:Dyclonine.png
Systematic (IUPAC) name
1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one
Clinical data
Trade names Sucrets
AHFS/Drugs.com monograph
  • US: C (Risk not ruled out)
Lozenge
Identifiers
586-60-7 7pxY
N01BX02 R02AD04
PubChem CID 3180
DrugBank DB00645 7pxY
ChemSpider 3068 7pxY
UNII 078A24Q30O 7pxY
KEGG D07881 7pxY
ChEBI CHEBI:4724 7pxY
ChEMBL CHEMBL1201217 7pxN
Chemical data
Formula C18H27NO2
289.413 g/mol
 14pxN (what is this?)  (verify)

Dyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge.[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.[2]

History

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

References

  1. ^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. Retrieved 2011-09-24. 
  2. ^ Gargiulo, A. V.; Burns, G. M.; Huck, C. P. (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois dental journal 61 (4): 303–304. PMID 1286862.  edit
  3. ^ a b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Retrieved 2011-09-24. Invented in Baltimore by Sharp & Dohme pharmaceutical in 1932, Sucrets have always been sold in the trademark metal box except for one 4 1/2-month period during the late 1960s when a tin shortage led to cardboard packaging, says [Frank Dzvonik]. 
  4. ^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". Associated Press in the New York Times. April 19, 1966. Retrieved 2011-09-24. 

External links



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