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Dysembryoplastic neuroepithelial tumour

Dysembryoplastic neuroepithelial tumour
File:DNET HE.jpg
Classification and external resources
ICD-O 9413/0
NCI Dysembryoplastic neuroepithelial tumour
Patient UK Dysembryoplastic neuroepithelial tumour
Dysembryoplastic neuroepithelial tumour, MRI FLAIR.

Dysembryoplastic neuroepithelial tumour, commonly abbreviated DNT or DNET, is a type of brain tumour.

Defined as "an usually supratentorial glial-neuronal neoplasm occurring in children and young adults and characterized by a predominantly cortical location and by drug-resistant partial seizures" [1]

It appears similar to oligodendroglioma, but with visible neurons.[2]

It is a benign tumor (Grade I of the WHO classification of brain tumours).[3][4]

It can cause epilepsy.[5]


Treatment of DNTs is usually surgical resection.[6]

See also


  1. ^ WHO Classification of Tumours of the Central Nervous System. WHO. 2007. ISBN 978-9283224303. 
  2. ^ O'Brien DF; Farrell M; Delanty N et al. (December 2007). "The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours". Br J Neurosurg 21 (6): 539–49. PMID 18071981. doi:10.1080/02688690701594817. 
  3. ^ Daumas-Duport C, Scheithauer B, Chodkiewicz J, Laws E, Vedrenne C (1988). "Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases". Neurosurgery 23 (5): 545–56. PMID 3143922. doi:10.1227/00006123-198811000-00002. 
  4. ^ Salah Uddin ABM, Jarmi T. Oligodendroglioma. URL: Accessed on: April 9, 2007.
  5. ^ Campos AR; Clusmann H; von Lehe M et al. (February 2009). "Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology". Neuroradiology 51 (7): 433–43. PMID 19242688. doi:10.1007/s00234-009-0511-1. 
  6. ^ Ray WZ; Blackburn SL; Casavilca-Zambrano S et al. (March 2009). "Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature". J. Neurooncol. 94 (2): 283–92. PMID 19267228. doi:10.1007/s11060-009-9849-9. 

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