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E2F5

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Identifiers
SymbolsE2F5 ; E2F-5
External IDsOMIM600967 MGI105091 HomoloGene1472 GeneCards: E2F5 Gene
RNA expression pattern
File:PBB GE E2F5 221586 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez187513559
EnsemblENSG00000133740ENSMUSG00000027552
UniProtQ15329Q61502
RefSeq (mRNA)NM_001083588NM_007892
RefSeq (protein)NP_001077057NP_031918
Location (UCSC)Chr 8:
86.09 – 86.13 Mb
Chr 3:
14.58 – 14.61 Mb
PubMed search[1][2]

Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.[1][2]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.[2]

Interactions

E2F5 has been shown to interact with TFDP1.[1][3]

See also

References

  1. ^ a b Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (April 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc Natl Acad Sci U S A 92 (6): 2403–7. PMC 42492. PMID 7892279. doi:10.1073/pnas.92.6.2403. 
  2. ^ a b "Entrez Gene: E2F5 E2F transcription factor 5, p130-binding". 
  3. ^ Hijmans, E M; Voorhoeve P M, Beijersbergen R L, van 't Veer L J, Bernards R (June 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. (UNITED STATES) 15 (6): 3082–9. ISSN 0270-7306. PMC 230539. PMID 7760804. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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