Open Access Articles- Top Results for E4F1


SymbolsE4F1 ; E4F
External IDsOMIM603022 MGI109530 HomoloGene3259 GeneCards: E4F1 Gene
RNA expression pattern
File:PBB GE E4F1 218524 at tn.png
More reference expression data
RefSeq (mRNA)NM_001288776NM_007893
RefSeq (protein)NP_001275705NP_031919
Location (UCSC)Chr 16:
2.27 – 2.29 Mb
Chr 17:
24.44 – 24.46 Mb
PubMed search[1][2]

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]


The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]


E4F1 has been shown to interact with:


  1. ^ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet 82 (1-2): 99–100. PMID 9763670. doi:10.1159/000015075. 
  2. ^ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW et al. (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res 6 (6): 525–37. PMID 8828041. doi:10.1101/gr.6.6.525. 
  3. ^ a b "Entrez Gene: E4F1 E4F transcription factor 1". 
  4. ^ a b Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ et al. (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–9. PMID 12446718. doi:10.1074/jbc.M210978200. 
  5. ^ Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ et al. (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene 19 (2): 188–99. PMID 10644996. doi:10.1038/sj.onc.1203250. 
  6. ^ Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E et al. (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. PMC 16614. PMID 10869426. doi:10.1073/pnas.130198397. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.