Open Access Articles- Top Results for EHF (gene)

EHF (gene)

SymbolsEHF ; ESE3; ESE3B; ESEJ
External IDsOMIM605439 MGI1270840 HomoloGene7301 GeneCards: EHF Gene
RNA expression pattern
File:PBB GE EHF 219850 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001206615NM_007914
RefSeq (protein)NP_001193544NP_031940
Location (UCSC)Chr 11:
34.64 – 34.68 Mb
Chr 2:
103.26 – 103.3 Mb
PubMed search[1][2]

ETS homologous factor is a protein that in humans is encoded by the EHF gene.[1][2] This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.[2]

Further reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).


  1. ^ Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun 264 (1): 119–26. PMID 10527851. doi:10.1006/bbrc.1999.1493. 
  2. ^ a b "Entrez Gene: EHF ets homologous factor". 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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