Open Access Articles- Top Results for ELK4


SymbolsELK4 ; SAP1
External IDsOMIM600246 MGI102853 HomoloGene1492 GeneCards: ELK4 Gene
RNA expression pattern
File:PBB GE ELK4 206919 at tn.png
File:PBB GE ELK4 205994 at tn.png
File:PBB GE ELK4 214831 at tn.png
More reference expression data
RefSeq (mRNA)NM_001973NM_007923
RefSeq (protein)NP_001964NP_031949
Location (UCSC)Chr 1:
205.58 – 205.6 Mb
Chr 1:
132.01 – 132.03 Mb
PubMed search[1][2]

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[1][2][3]


This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[3]


ELK4 has been shown to interact with:


  1. Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics 23 (3): 710–1. PMID 7851904. doi:10.1006/geno.1994.1564. 
  2. Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics 29 (3): 769–72. PMID 8575773. doi:10.1006/geno.1995.9938. 
  3. 3.0 3.1 "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)". 
  4. Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K et al. (Mar 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene 20 (11): 1357–67. PMID 11313879. doi:10.1038/sj.onc.1204256. 
  5. Hassler M, Richmond TJ (Jun 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. PMC 150215. PMID 11406578. doi:10.1093/emboj/20.12.3018. 
  6. Zhu C, Johansen FE, Prywes R (Sep 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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