Open Access Articles- Top Results for EMDT


Systematic (IUPAC) name
Clinical data
PubChem CID 6918513
IUPHAR ligand 12
ChemSpider 5293710 7pxN
Chemical data
Formula C15H22N2O
246.347 g/mol
 14pxN (what is this?)  (verify)

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor.[1] EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885.[2] Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.[3]

See also


  1. ^ Glennon, RA; Lee, M; Rangisetty, JB; Dukat, M; Roth, BL; Savage, JE; McBride, A; Rauser, L; Hufeisen, S (2000). "2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors". Journal of Medical Chemistry 43 (5): 1011–8. PMID 10715164. doi:10.1021/jm990550b. 
  2. ^ Meneses, A; Perez-Garcia, G; Liy-Salmeron, G; Flores-Galvez, D; Castillo, C; Castillo, E (2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research 195 (1): 112–9. PMID 18191236. doi:10.1016/j.bbr.2007.11.023. 
  3. ^ Svenningsson P, Tzavara ET, Qi H, Carruthers R, Witkin JM, Nomikos GG, Greengard P (April 2007). "Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation". The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 27 (15): 4201–9. PMID 17428998. doi:10.1523/JNEUROSCI.3110-06.2007.