Open Access Articles- Top Results for EP1 receptor

EP1 receptor

SymbolsPTGER1 ; EP1
External IDsOMIM176802 MGI97793 HomoloGene738 IUPHAR: 340 ChEMBL: 1811 GeneCards: PTGER1 Gene
RNA expression pattern
File:PBB GE PTGER1 214391 x at tn.png
File:PBB GE PTGER1 207650 x at tn.png
More reference expression data
RefSeq (mRNA)NM_000955NM_013641
RefSeq (protein)NP_000946NP_038669
Location (UCSC)Chr 19:
14.58 – 14.59 Mb
Chr 8:
83.67 – 83.67 Mb
PubMed search[1][2]

Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.[1]

See also


External links

  • "Prostanoid Receptors: EP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading


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