Open Access Articles- Top Results for EP4 receptor

EP4 receptor

SymbolsPTGER4 ; EP4; EP4R
External IDsOMIM601586 MGI104311 HomoloGene20261 IUPHAR: 343 ChEMBL: 1836 GeneCards: PTGER4 Gene
RefSeq (mRNA)NM_000958NM_001136079
RefSeq (protein)NP_000949NP_001129551
Location (UCSC)Chr 5:
40.68 – 40.69 Mb
Chr 15:
5.21 – 5.24 Mb
PubMed search[1][2]

Prostaglandin E receptor 4 (EP4) is a prostaglandin receptor encoded by the PTGER4 gene in humans.

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.[1]

See also


External links

  • "Prostanoid Receptors: EP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading


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