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EPHB6

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Identifiers
SymbolsEPHB6 ; HEP
External IDsOMIM602757 MGI1096338 HomoloGene20940 IUPHAR: 1834 ChEMBL: 5836 GeneCards: EPHB6 Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE EPHB6 204718 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez205113848
EnsemblENSG00000106123ENSMUSG00000029869
UniProtO15197O08644
RefSeq (mRNA)NM_001280794NM_001146351
RefSeq (protein)NP_001267723NP_001139823
Location (UCSC)Chr 7:
142.55 – 142.57 Mb
Chr 6:
41.61 – 41.62 Mb
PubMed search[1][2]

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.[1]

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Further reading

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