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EPH receptor A3

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Identifiers
SymbolsEPHA3 ; EK4; ETK; ETK1; HEK; HEK4; TYRO4
External IDsOMIM179611 MGI99612 HomoloGene21083 IUPHAR: 1823 ChEMBL: 4954 GeneCards: EPHA3 Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE EPHA3 206070 s at tn.png
File:PBB GE EPHA3 206071 s at tn.png
File:PBB GE EPHA3 gnf1h09694 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez204213837
EnsemblENSG00000044524ENSMUSG00000052504
UniProtP29320P29319
RefSeq (mRNA)NM_005233NM_010140
RefSeq (protein)NP_005224NP_034270
Location (UCSC)Chr 3:
89.16 – 89.53 Mb
Chr 16:
63.54 – 63.86 Mb
PubMed search[1][2]

EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene.[1][2][3]

Function

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.[3]

Interactions

EPH receptor A3 has been shown to interact with EFNB2[4][5] and EFNA5.[5][6]

References

  1. Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A et al. (March 1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line". J Biol Chem 267 (5): 3262–7. PMID 1737782. 
  2. Wicks IP, Wilkinson D, Salvaris E, Boyd AW (April 1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines". Proc Natl Acad Sci U S A 89 (5): 1611–5. PMC 48502. PMID 1311845. doi:10.1073/pnas.89.5.1611. 
  3. 3.0 3.1 "Entrez Gene: EPHA3 EPH receptor A3". 
  4. Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E et al. (November 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Mol. Immunol. 32 (16): 1197–205. PMID 8559144. doi:10.1016/0161-5890(95)00108-5. 
  5. 5.0 5.1 Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF et al. (June 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor". J. Biol. Chem. 272 (26): 16521–30. PMID 9195962. doi:10.1074/jbc.272.26.16521. 
  6. Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (August 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine 9 (8): 540–9. PMID 9245480. doi:10.1006/cyto.1997.0199. 

Further reading

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