Open Access Articles- Top Results for EPH receptor A4

EPH receptor A4

SymbolsEPHA4 ; HEK8; SEK; TYRO1
External IDsOMIM602188 MGI98277 HomoloGene20933 IUPHAR: 1824 ChEMBL: 3988 GeneCards: EPHA4 Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE EPHA4 206114 at tn.png
File:PBB GE EPHA4 gnf1h07687 at tn.png
More reference expression data
RefSeq (mRNA)NM_004438NM_007936
RefSeq (protein)NP_004429NP_031962
Location (UCSC)Chr 2:
222.28 – 222.44 Mb
Chr 1:
77.37 – 77.52 Mb
PubMed search[1][2]

EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene.[1][2]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[2]

In 2012, a publication in Nature medicine revealed a connection between EPHA4 and the neurodegenerative disease Amyotrophic lateral sclerosis (ALS), where a defective gene allows ALS patients to live considerably longer than patients with an intact gene. This opens up for development of treatment for this, currently untreatable, disease.


  1. ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. PMID 9267020. doi:10.1016/S0092-8674(00)80500-0. 
  2. ^ a b "Entrez Gene: EPHA4 EPH receptor A4". 

Further reading

  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. PMID 9530499. doi:10.1146/annurev.neuro.21.1.309. 
  • Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626. doi:10.1016/S0163-7258(97)00112-5. 
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology 196: 177–244. ISBN 978-0-12-364600-2. PMID 10730216. doi:10.1016/S0074-7696(00)96005-4.  |chapter= ignored (help)
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. PMC 1692797. PMID 11128993. doi:10.1098/rstb.2000.0635. 
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076. doi:10.1038/35058515. 
  • Fox GM, Holst PL, Chute HT et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene 10 (5): 897–905. PMID 7898931. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Ellis C, Kasmi F, Ganju P et al. (1996). "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn". Oncogene 12 (8): 1727–36. PMID 8622893. 
  • Gale NW, Holland SJ, Valenzuela DM et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron 17 (1): 9–19. PMID 8755474. doi:10.1016/S0896-6273(00)80276-7. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • Aasheim HC, Terstappen LW, Logtenberg T (1997). "Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis". Blood 90 (9): 3613–22. PMID 9345045. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Bergemann AD, Zhang L, Chiang MK et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube". Oncogene 16 (4): 471–80. PMID 9484836. doi:10.1038/sj.onc.1201557. 
  • Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum". J. Neurosci. 19 (12): 4962–71. PMID 10366629. 

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