Open Access Articles- Top Results for Efonidipine


Systematic (IUPAC) name
2-(phenyl-(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-2-oxo-1,3-dioxa-2λ5-phosphacyclohex-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
Clinical data
AHFS/ International Drug Names
  • (Prescription only)
111011-63-3 7pxY
PubChem CID 119171
ChemSpider 106463 7pxN
UNII 40ZTP2T37Q 7pxY
Chemical data
Formula C34H38N3O7P
631.65 g/mol
 14pxN (what is this?)  (verify)

Efonidipine (INN) is a dihydropyridine calcium channel blocker marketed by Shionogi & Co. of Japan. It was launched in 1995, under the brand name Landel. The drug blocks both T-type and L-type calcium channels.[1]

It has also been studied in atherosclerosis[2] and acute renal failure.[3]


  1. ^ Tanaka H, Shigenobu K (2002). "Efonidipine hydrochloride: a dual blocker of L- and T-type Ca2+ channels". Cardiovasc. Drug Rev. 20 (1): 81–92. PMID 12070536. 
  2. ^ Toyoda K, Kitahara M, Yamashita T et al. (May 1994). "[Effect of efonidipine hydrochloride (NZ-105), a new dihydropyridine calcium antagonist, on the experimental atherosclerosis in cholesterol-fed rabbits]". Nippon Yakurigaku Zasshi (in Japanese) 103 (5): 231–9. PMID 8188119. 
  3. ^ Shudo C, Masuda Y, Sugita H, Tanaka S, Tomita K (November 1994). "Effects of efonidipine hydrochloride (NZ-105), a new calcium antagonist, against acute renal failure in rats". Gen. Pharmacol. 25 (7): 1451–8. PMID 7896060. 

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