Endothelin receptor antagonist
Three main kinds of ERAs exist:
- selective ETA receptor antagonists (sitaxentan, ambrisentan, atrasentan, BQ-123, zibotentan), which affect endothelin A receptors.
- dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors.
- selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage.
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