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Open Access Articles- Top Results for Epinastine

Epinastine

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Epinastine
File:Epinastine.svg
Systematic (IUPAC) name
(RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
Clinical data
Trade names Alesion, Elestat, Purivist, Relestat
AHFS/Drugs.com monograph
MedlinePlus a604011
  • C
Eye drops
Pharmacokinetic data
Protein binding 64%
Half-life 12 hours
Identifiers
80012-43-7 7pxY
R06AX24 S01GX10
PubChem CID 3241
DrugBank DB00751 7pxY
ChemSpider 3128 7pxY
UNII Q13WX941EF 7pxY
KEGG D07900 7pxY
ChEBI CHEBI:51032 7pxY
ChEMBL CHEMBL1106 7pxY
Chemical data
Formula C16H15N3
249.311 g/mol
 14pxY (what is this?)  (verify)

Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.[1] It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.[2]

References

  1. ^ Pradhan, S; Abhishek, K; Mah, F (2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert opinion on drug metabolism & toxicology 5 (9): 1135–40. PMID 19630694. doi:10.1517/17425250903117284. 
  2. ^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung 40 (4): 440–6. PMID 1972625. 

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