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epsilon-Amanitin

ε-Amanitin
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Other names
Amanine
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21705-02-2
ChemSpider 26234941 7pxY
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C39H53N9O14S
Molar mass 903.96 g/mol
Appearance Colorless, crystalline solid
Soluble
Solubility in ethanol and methanol Soluble
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

epsilon-Amanitin or ε-amanitin is a Cyclic peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral LD50 of ε-amanitin is approximately 0.1 mg/kg.

Toxicology

Like other amatoxins, ε-amanitin an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]

See also

References

  1. ^ M. Cochet-Meillhac and Chambon P. (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim Biophys Acta 353 (2): 160–184. PMID 4601749. doi:10.1016/0005-2787(74)90182-8. 

External links