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Esmirtazapine

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Esmirtazapine
200px
Systematic (IUPAC) name
(S)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine
Clinical data
  • Uncontrolled
Oral
Pharmacokinetic data
Metabolism Liver (CYP2D6)[1]
Identifiers
61337-87-9 7pxY
None
PubChem CID 3085218
ChemSpider 2342166 7pxY
UNII 4685R51V7M 7pxY
KEGG D04055 7pxY
Chemical data
Formula C17H19N3
265.35 g/mol
Physical data
Melting point Script error: No such module "convert".
Soluble in methanol and chloroform mg/mL (20 °C)
 14pxY (what is this?)  (verify)

Esmirtazapine (ORG-50,081) is a drug which was under development by Organon for the treatment of insomnia and vasomotor symptoms (e.g., hot flashes) associated with menopause.[2][3][4][5] Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology, including inverse agonist actions at H1 and 5-HT2 receptors and antagonist actions at α2-adrenergic receptors.[2][6] As of March 2010, Merck terminated internal clinical development program for esmirtazapine, for hot flashes and insomnia, for strategic reasons.[7]

See also

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