Adverts

Open Access Articles- Top Results for Eterobarb

Eterobarb

</th></tr>
Eterobarb
File:Eterobarb.png
Systematic (IUPAC) name
5-ethyl-1,3-bis(methoxymethyl)-5-phenyl-1,3-diazinane-2,4,6-trione
Clinical data
Oral
Identifiers
27511-99-5 7pxY
None
PubChem CID 33925
ChemSpider 31271 7pxN
UNII 432SI047GA 7pxY
KEGG D04077 7pxY
Chemical data
Formula C16H20N2O5
320.340 g/mol
 14pxN (what is this?)  (verify)

Eterobarb (Antilon) is a barbiturate derivative. It has mainly anticonvulsant action with less sedative effects than the closely related compound phenobarbital. It saw reasonable success in clinical trials, but is not in widespread medical use.[1][2]

Synthesis

File:Eterobarb synthesis.png
Eterobarb synthesis, Lednicer book 2

Sodium phenobarbital serves as its own base (so the yield is limited to 50%) and reacts readily with "chloro(methoxy)methane" to produce eterobarb.[3]


References

  1. ^ Gallagher, BB; Baumel, IP; Woodbury, SG; Dimicco, JA (1975). "Clinical evaluation of eterobarb, a new anticonvulsant drug". Neurology 25 (5): 399–404. PMID 1094318. doi:10.1212/wnl.25.5.399. 
  2. ^ Smith, DB; Goldstein, SG; Roomet, A (1986). "A comparison of the toxicity effects of the anticonvulsant eterobarb (antilon, DMMP) and phenobarbital in normal human volunteers". Epilepsia 27 (2): 149–55. PMID 3956454. doi:10.1111/j.1528-1157.1986.tb03518.x. 
  3. ^ Vida, Julius A. (1971). "Anticonvulsants. 1. Alkoxymethyl derivatives of barbiturates and diphenylhydantoin". Journal of Medicinal Chemistry 14 (3): 187–189. doi:10.1021/jm00285a002.  edit


Lua error in package.lua at line 80: module 'Module:Buffer' not found.