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Open Access Articles- Top Results for Ethacridine lactate

Ethacridine lactate

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Ethacridine lactate
Skeletal formulas of ethacridine lactate
Ball-and-stick models of the component ions of ethacridine lactate
Systematic (IUPAC) name
7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
1837-57-6 7pxN
B05CA08 D08AA01
PubChem CID 15789
ChemSpider 15012 7pxY
KEGG D01248 7pxY
ChEMBL CHEMBL582355 7pxY
Chemical data
Formula C18H21N3O4
343.37
 14pxN (what is this?)  (verify)

Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%.

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References

  • Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology 61 (6): 733–736. PMID 6843933.  edit
  • Merck Index, 11th Ed., 3668.