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Open Access Articles- Top Results for Ethinamate

Ethinamate

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Ethinamate
File:Ethinamate.svg
Systematic (IUPAC) name
(1-ethynylcyclohexyl)carbamate
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
  • (Prescription only)
Oral
Identifiers
126-52-3 7pxY
None
PubChem CID 3284
DrugBank DB01031 7pxY
ChemSpider 3169 7pxY
UNII IAN371PP48 7pxY
KEGG D00703 7pxY
ChEBI CHEBI:4884 7pxY
ChEMBL CHEMBL1576 7pxY
Chemical data
Formula C9H13NO2
167.205 g/mol
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Ethinamate (Valamin, Valmid) is a short-acting carbamate-derivative sedative-hypnotic medication used to treat insomnia. Regular use leads to drug tolerance, and it is usually not effective for more than 7 days. Prolonged use can lead to dependency.

Ethinamate has been replaced by other medicines (particularly benzodiazepines), and it is not available in the Netherlands, the United States or Canada.

Chemistry

Ethinamate (1-ethynylcyclohexanone carbamate) is synthesized by combining acetylene with cyclohexanone and then transforming the resulting carbinol into a carbamate by the subsequent reaction with phosgene, and later with ammonia. Some lithium metal or similar is used to make the acetylene react with the cyclohexanone in the first step.[1][2]

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References

  1. ^ H. Pfeiffer, K. Junkman, U.S. Patent 2,816,910 (1957)
  2. ^ H. Emde, W. Grimme, DE 1021843  (1953)



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