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Ethisterone

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Ethisterone
File:Ethisterone.png
File:Etisterona3D.png
Systematic (IUPAC) name
(8R,9S,10R,13R,14S,17R)-17-Ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Clinical data
Identifiers
434-03-7 7pxN
G03DC04
PubChem CID 5284557
ChemSpider 4447612 7pxY
UNII Verifiedfields = changed P201BVY1MJ Verifiedfields = changed 7pxN
ChEBI CHEBI:34749 7pxN
ChEMBL CHEMBL241694 7pxY
Chemical data
Formula C21H28O2
312.446 g/mol
 14pxN (what is this?)  (verify)

Ethisterone (pregneninolone, 17α-ethynyltestosterone or 19–norandrostane) is a progestin. It is the 17α-ethynyl analog of testosterone, and was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin and marketed in Germany in 1939 as Proluton C and by Schering in the U.S. in 1945 as Pranone. It was the first orally-active progestin.

Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel (Ciba, Organon, Roussel).

References