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Open Access Articles- Top Results for Ethoxzolamide

Ethoxzolamide

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Ethoxzolamide
File:Ethoxzolamide structure.svg
File:Ethoxzolamide ball-and-stick.png
Systematic (IUPAC) name
6-ethoxy-1,3-benzothiazole-2-sulfonamide
Clinical data
Pharmacokinetic data
Protein binding ~89%
Half-life 2.5-5.5 hours
Identifiers
452-35-7 7pxY
None
PubChem CID 3295
DrugBank DB00311 7pxY
ChemSpider 3179 7pxY
UNII Z52H4811WX 7pxY
KEGG D02441 7pxY
ChEBI CHEBI:101096 7pxY
ChEMBL CHEMBL18 7pxY
Chemical data
Formula C9H10N2O3S2
258.319 g/mol
 14pxY (what is this?)  (verify)

Ethoxzolamide (alternatively known as Ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. It is used in the treatment of glaucoma and duodenal ulcers, and as a diuretic. It may also be used in the treatment of some forms of epilepsy.

Pharmacology

Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Mechanism of action

Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems.

Synthesis

File:Ethoxzolamide synthesis.svg
Ethoxzolamide synthesis: GB 795174 ; J. Korman, U.S. Patent 2,868,800 (1958, 1959 both to Upjohn).

See also