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Open Access Articles- Top Results for FASTK

FASTK

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Identifiers
SymbolsFASTK ; FAST
External IDsOMIM606965 MGI1913837 HomoloGene4884 GeneCards: FASTK Gene
EC number2.7.11.8
RNA expression pattern
File:PBB GE FASTK 214114 x at tn.png
File:PBB GE FASTK 202676 x at tn.png
File:PBB GE FASTK 210975 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1092266587
EnsemblENSG00000164896ENSMUSG00000028959
UniProtQ14296Q9JIX9
RefSeq (mRNA)NM_001258461NM_023229
RefSeq (protein)NP_001245390NP_075718
Location (UCSC)Chr 7:
150.77 – 150.78 Mb
Chr 5:
24.44 – 24.45 Mb
PubMed search[1][2]

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.[1][2][3]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.[3]

References

Further reading

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