Open Access Articles- Top Results for FBLN2


External IDsOMIM135821 MGI95488 HomoloGene1514 GeneCards: FBLN2 Gene
RNA expression pattern
File:PBB GE FBLN2 203886 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001004019NM_001081437
RefSeq (protein)NP_001004019NP_001074906
Location (UCSC)Chr 3:
13.57 – 13.68 Mb
Chr 6:
91.21 – 91.27 Mb
PubMed search[1][2]

Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.[1][2]

This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


FBLN2 has been shown to interact with Laminin, alpha 1,[3][4] Laminin, alpha 5[3] and Perlecan.[5][6]


  1. ^ Zhang RZ, Pan TC, Zhang ZY, Mattei MG, Timpl R, Chu ML (January 1995). "Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes". Genomics 22 (2): 425–30. PMID 7806230. doi:10.1006/geno.1994.1404. 
  2. ^ a b "Entrez Gene: FBLN2 fibulin 2". 
  3. ^ a b Utani, A; Nomizu M; Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". J. Biol. Chem. (UNITED STATES) 272 (5): 2814–20. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. 
  4. ^ Talts, J F; Sasaki T; Miosge N; Göhring W; Mann K; Mayne R; Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues". J. Biol. Chem. (UNITED STATES) 275 (45): 35192–9. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. 
  5. ^ Hopf, M; Göhring W; Mann K; Timpl R (August 2001). "Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan". J. Mol. Biol. (England) 311 (3): 529–41. ISSN 0022-2836. PMID 11493006. doi:10.1006/jmbi.2001.4878. 
  6. ^ Sasaki, T; Göhring W; Pan T C; Chu M L; Timpl R (December 1995). "Binding of mouse and human fibulin-2 to extracellular matrix ligands". J. Mol. Biol. (ENGLAND) 254 (5): 892–9. ISSN 0022-2836. PMID 7500359. doi:10.1006/jmbi.1995.0664. 

Further reading


Lua error in package.lua at line 80: module 'Module:Buffer' not found.