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Open Access Articles- Top Results for FER (gene)

FER (gene)

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Identifiers
SymbolsFER ; FerT; PPP1R74; Pe1Fe10; Pe1Fe13; Pe1Fe3; Pe1Fe6; TYK3
External IDsOMIM176942 MGI105917 HomoloGene74300 IUPHAR: 2022 ChEMBL: 3982 GeneCards: FER Gene
EC number2.7.10.2
Orthologs
SpeciesHumanMouse
Entrez224114158
EnsemblENSG00000151422ENSMUSG00000000127
UniProtP16591P70451
RefSeq (mRNA)NM_005246NM_001037997
RefSeq (protein)NP_005237NP_001033086
Location (UCSC)Chr 5:
108.08 – 108.53 Mb
Chr 17:
63.9 – 64.14 Mb
PubMed search[1][2]

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.[1]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.[1]

Interactions

FER (gene) has been shown to interact with TMF1[2] and Cortactin.[3]

References

  1. ^ a b "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)". 
  2. ^ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. (NETHERLANDS) 434 (3): 339–45. ISSN 0014-5793. PMID 9742951. doi:10.1016/S0014-5793(98)01003-5. 
  3. ^ Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. (UNITED STATES) 273 (36): 23542–8. ISSN 0021-9258. PMID 9722593. doi:10.1074/jbc.273.36.23542. 

Further reading

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