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FGG

This article is about the gene. For the sports organization, see Federation of Gay Games. For the Susumu Hirasawa song, see The Ghost in Science.
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Identifiers
SymbolFGG
External IDsOMIM134850 MGI95526 HomoloGene429 ChEMBL: 4058 GeneCards: FGG Gene
RNA expression pattern
File:PBB GE FGG 219612 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez226699571
EnsemblENSG00000171557ENSMUSG00000033860
UniProtP02679Q8VCM7
RefSeq (mRNA)NM_000509NM_133862
RefSeq (protein)NP_000500NP_598623
Location (UCSC)Chr 4:
155.53 – 155.53 Mb
Chr 3:
83.01 – 83.02 Mb
PubMed search[1][2]

Fibrinogen gamma chain, also known as FGG, is a human gene found on Chromosome 4.

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.[1] Alternative splicing of the mRNA chain results in two transcript variants; the common γA chain and the alternatively spliced γ' chain. Approximately 10% of the total plasma fibrinogen consists of γA/γ' fibrinogen, with <1% consisting of γ'/γ' fibrinogen. Increased and decreased levels of γA/γ' fibrinogen have been associated with CAD and DVT respectively.

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Further reading

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