Open Access Articles- Top Results for FOSL1


SymbolsFOSL1 ; FRA; FRA1; fra-1
External IDsOMIM136515 MGI107179 HomoloGene3967 GeneCards: FOSL1 Gene
RNA expression pattern
File:PBB GE FOSL1 204420 at tn.png
File:PBB GE FOSL1 213250 at tn.png
More reference expression data
RefSeq (mRNA)NM_001300844NM_010235
RefSeq (protein)NP_001287773NP_034365
Location (UCSC)Chr 11:
65.66 – 65.67 Mb
Chr 19:
5.45 – 5.46 Mb
PubMed search[1][2]

Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene.[1][2]

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[2]


FOSL1 has been shown to interact with USF1 (human gene)[3] and C-jun.[3]

See also


  1. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Apr 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene 5 (3): 249–55. PMID 2107490. 
  2. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1". 
  3. ^ a b Pognonec, P; Boulukos K E; Aperlo C; Fujimoto M; Ariga H; Nomoto A; Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene (ENGLAND) 14 (17): 2091–8. ISSN 0950-9232. PMID 9160889. doi:10.1038/sj.onc.1201046. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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