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Open Access Articles- Top Results for FOXJ1

FOXJ1

Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene.[1] It has been shown that this gene is a transcription factor involved in ciliogenesis.[2]

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Identifiers
SymbolsFOXJ1 ; FKHL13; HFH-4; HFH4
External IDsOMIM602291 MGI1347474 HomoloGene1117 GeneCards: FOXJ1 Gene
Orthologs
SpeciesHumanMouse
Entrez230215223
EnsemblENSG00000129654ENSMUSG00000034227
UniProtQ92949Q61660
RefSeq (mRNA)NM_001454NM_008240
RefSeq (protein)NP_001445NP_032266
Location (UCSC)Chr 17:
74.13 – 74.14 Mb
Chr 11:
116.33 – 116.34 Mb
PubMed search[1][2]

Function

This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry.[1]

Clinical significance

Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[1]

References

  1. ^ a b c "Entrez Gene: forkhead box J1". 
  2. ^ Yu X, Ng CP, Habacher H, Roy S (December 2008). "Foxj1 transcription factors are master regulators of the motile ciliogenic program". Nat. Genet. 40 (12): 1445–53. PMID 19011630. doi:10.1038/ng.263. 

Further reading

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