Open Access Articles- Top Results for FOXN1


SymbolsFOXN1 ; FKHL20; RONU; WHN
External IDsOMIM600838 MGI102949 HomoloGene2664 GeneCards: FOXN1 Gene
RNA expression pattern
File:PBB GE FOXN1 207683 at tn.png
More reference expression data
RefSeq (mRNA)NM_003593NM_001277290
RefSeq (protein)NP_003584NP_001264219
Location (UCSC)Chr 17:
26.83 – 26.87 Mb
Chr 11:
78.36 – 78.39 Mb
PubMed search[1][2]

Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1 gene.[1][2]

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.[2] In the chick embryo, the FOXN1 gene is expressed in the developing thymus, claws and feathers. The expression of FOXN1 in feathers and claws indicates that it may regulate the feather outgrowth. In feather and claws, FOXN1 can potentially regulate expression of keratins similar to mammalian orthologs. [3]


  1. ^ Schorpp M, Hofmann M, Dear TN, Boehm T (Dec 1997). "Characterization of mouse and human nude genes". Immunogenetics 46 (6): 509–15. PMID 9321431. doi:10.1007/s002510050312. 
  2. ^ a b "Entrez Gene: FOXN1 forkhead box N1". 
  3. ^ Darnell DK, Zhang LS, Hannenhalli S, Yaklichkin S. (Dec 2014). "Developmental expression of chicken FOXN1 and putative target genes during feather development.". Int J Dev Biol. 58 (1): 57–64. PMID 24860996. doi:10.1387/ijdb.130023sy. 

Further reading