SymbolsFYN ; SLK; SYN; p59-FYN
External IDsOMIM137025 MGI95602 HomoloGene48068 IUPHAR: 2026 ChEMBL: 1841 GeneCards: FYN Gene
EC number2.7.10.2
RNA expression pattern
File:PBB GE FYN 210105 s at tn.png
File:PBB GE FYN 212486 s at tn.png
File:PBB GE FYN 216033 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001242779NM_001122892
RefSeq (protein)NP_002028NP_001116364
Location (UCSC)Chr 6:
111.98 – 112.19 Mb
Chr 10:
39.37 – 39.57 Mb
PubMed search[1][2]

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.[1]

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.[2]


Fyn is a protein, present in the signaling pathway of integrins, which activates ras. Fyn is a tyrosine-specific phospho-transferase that is a member of the Src family of tyrosine protein kinases.[3] Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane, where it phosphorylates tyrosine residues on key targets involved in a variety of different signaling pathways. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules.

Role in signaling pathways

At least three tools have been useful in discerning a requirement for Fyn function in a particular signaling system:

  • cells derived from Fyn-/- mice (as well as cells derived from Fyn, Src, Yes, Fyn triple knockout mice (SYF));
  • a kinase-inactive, dominant negative mutant form of Fyn (K299M);
  • pharmacologic inhibitors of Src family kinases, such as PP2; note that PP2 also inhibits other tyrosine protein kinases such as Abl, PDGFR and c-Kit.

Using these tools, a requirement for Fyn has been shown for the following signaling pathways: T and B cell receptor signaling,[4][5] integrin-mediated signaling, growth factor and cytokine receptor signaling, platelet activation, ion channel function, cell adhesion, axon guidance, fertilization, entry into mitosis, and differentiation of natural killer cells, oligodendrocytes and keratinocytes.


FYN has been shown to interact with:


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  2. ^ "Entrez Gene: FYN FYN oncogene related to SRC, FGR, YES". 
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  7. ^ Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK (April 2000). "Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells". Exp. Cell Res. 256 (1): 168–78. PMID 10739664. doi:10.1006/excr.2000.4822. 
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Further reading