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FZD2

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Identifiers
SymbolsFZD2 ; Fz2; fz-2; fzE2; hFz2
External IDsOMIM600667 MGI1888513 HomoloGene20377 IUPHAR: 230 GeneCards: FZD2 Gene
RNA expression pattern
File:PBB GE FZD2 210220 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez253557265
EnsemblENSG00000180340ENSMUSG00000050288
UniProtQ14332Q9JIP6
RefSeq (mRNA)NM_001466NM_020510
RefSeq (protein)NP_001457NP_065256
Location (UCSC)Chr 17:
42.63 – 42.64 Mb
Chr 11:
102.6 – 102.61 Mb
PubMed search[1][2]

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.[3]

See also

References

  1. ^ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics 27 (2): 370–3. PMID 7558010. doi:10.1006/geno.1995.1060. 
  2. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. PMID 9813155. doi:10.1006/bbrc.1998.9607. 
  3. ^ a b "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)". 

External links

  • "Frizzled Receptors: FZD2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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